Archive for the ‘Refunds for Breast Cancer Research’ Category

Breast Cancer Researcher? Apply Now for a PBCC Research Grant!

Posted By on July 15th, 2015 at 11:09 am | 0 comments.

Dr.-Hua-Check-PresentationPennsylvania breast cancer researchers have life-changing ideas. The PA Breast Cancer Coalition wants to help them get those ideas off the ground. We are now accepting applications for the 2016 PA Breast Cancer Coalition Research Grant program. Each year, this program offers funding to cancer researchers in Pennsylvania working to find the cause of and cure for breast cancer as well as improved treatments. Letters of Intent are due July 29.

Want to apply?

The PBCC Research Grants program serves as a catalyst for scientists working every day on cutting-edge treatment ideas for women battling breast cancer.  Grants are awarded by a peer review panel of expert scientists and advocates.

If you are interested in applying, please fill out the application and budget forms on our website by clicking here.  If you have questions about our application process, contact Michelle@PABreastCancer.org or call 717-769-2308.  Thank you for working to find a cure for breast cancer now… so our daughters won’t have to!

Your Donations at Work: Penn State Hershey’s Dr. Craig Meyers Publishes Results of Triple-Negative Breast Cancer Study

Posted By on May 15th, 2015 at 8:30 am | 0 comments.

Dr-Meyers-and-BoardThe research of Dr. Craig Meyers and his team at Penn State College of Medicine, which was funded by the PA Breast Cancer Coalition, has been published in Cancer Biology and Therapy. They have determined that a virus not known to cause disease kills triple-negative breast cancer cells and killed tumors grown from these cells in mice. Understanding how the virus kills cancer may lead to new treatments for breast cancer.

Adeno-associated virus type 2 (AAV2) infects humans but is not known to cause sickness. In prior studies, the researchers tested the virus on a variety of breast cancers that represent degrees of aggressiveness and on human papillomavirus-positive cervical cancer cells. The virus initiated apoptosis — natural cell death — in cancer cells without affecting healthy cells.
“Treatment of breast cancer remains difficult because there are multiple signaling pathways that promote tumor growth and develop resistance to treatment,” said Craig Meyers, Ph.D., Distinguished Professor of Microbiology and Immunology.
Signaling pathways involve molecules in a cell that control cell functions — like cell division — by cooperation. For example, the first molecule in the process receives a signal to begin. It then tells another molecule to work, and so on.
Treatment of breast cancer differs by patient due to differences in tumors. Some tumors contain protein receptors that are activated by the hormones estrogen or progesterone. Others respond to another protein called human epidermal growth factor receptor 2, or HER2. Each of these is treated differently.
A triple-negative breast cancer does not have any of these protein receptors and is typically aggressive.
“There is an urgent and ongoing need for the development of novel therapies which efficiently target triple-negative breast cancers,” Meyers said.
In the current study, the researchers tested AAV2 on a cell-line representative of triple-negative breast cancer. The researchers report their results in Cancer Biology & Therapy.
The AAV2 killed 100 percent of the cells in the laboratory by activating proteins called caspases, which are essential for the cell’s natural death. In addition, consistent with past studies, AAV2-infected cancer cells produced more Ki-67, an immunity system activating protein and c-Myc, a protein that helps both to increase cell growth and induce apoptosis. The cancer cell growth slowed by day 17 and all cells were dead by day 21. AAV2 mediated cell killing of multiple breast cancer cell lines representing both low and high grades of cancer and targeted the cancer cells independent of hormone or growth factor classification.
The researchers then injected AAV2 into human breast cancer cell line-derived tumors in mice without functioning immune systems. Mice that received AAV2 outlived the untreated mice and did not show signs of being sick, unlike the untreated mice. Tumor sizes decreased in the treated mice, areas of cell death were visible, and all AAV2 treated mice survived through the study, a direct contrast to the untreated mice.
“These results are significant, since tumor necrosis — or death — in response to therapy is also used as the measure of an effective chemotherapeutic,” Meyers said.
Future studies should look at the use of AAV2 body-wide in mice, which would better model what happens in humans.
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Other researchers on this project are Samina Alam, research associate, Penn State; Brian Bowser, PPD Vaccines and Biologics Laboratory; Mohd Israr, Feinstein Institute for Medical Research; and Michael Conway, Central Michigan University College of Medicine.
The Pennsylvania Breast Cancer Coalition funded this research.

To read the complete article online, click here.

 

File your Taxes, Fight Breast Cancer: Penn Researcher Focused on HER2+ Breast Cancer Wins $50,000 PBCC Grant

Posted By on April 15th, 2015 at 8:39 am | 949 comments.

patheadshotforplBy Pat Halpin-Murphy, President & Founder

You… yes, YOU can make a difference this time every year. I’m talking about the choices you make when filing your taxes. On Line 32, you can choose to donate your state income tax refund directly to breast cancer researchers in Pennsylvania who are working to find a cure. It’s part of the PBCC’s Refunds for Breast Cancer Research initiative.

Earlier this month, I had the pleasure of meeting Dr. Xianxin Hua, a researcher at the University of Pennsylvania Abramson Family Cancer Research Institute working on treatments for HER2+ breast cancer. The PBCC awarded Dr. Hua with a $50,000 grant to build progress and advancements in the lab. Dr. Hua is one of three grant winners this year. Drs. Alessandro Fatatis and Mauricio Reginato of the Drexel University College of Medicine also received Refunds for Research funding.

Maybe you already have made a difference this tax season. If you have, on behalf of the thousands of women and families touched by breast cancer, I thank you. You are providing hope and much-needed support for the brilliant minds at work in laboratories across the state!

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YOU can make a real difference this tax season. Donate your state income tax refund to breast cancer research by choosing “Option A” on Line 32. Help us continue our fight against breast cancer! For more information on the PBCC’s Refunds for Research program, visit pbcc.me/refunds.

PBCC Awards Drexel Researchers Working to Find Breast Cancer Cure

Posted By on March 16th, 2015 at 8:37 am | 811 comments.

patheadshotforplIt’s not every day you get to witness real hope in action. Innovative, groundbreaking and awe-inspiring breast cancer research is happening right now in Pennsylvania. The PA Breast Cancer Coalition presented Refunds for Breast Cancer Research grants for $50,000 each to Drs. Alessandro Fatatis and Mauricio Reginato of Drexel University College of Medicine last week. Touring their laboratories and learning more about their exciting research was captivating.

Dr. Fatatis is focused on metastatic breast cancer and how to stop the cancer cells from spreading. He plans to use the Refunds for Research grant to ready his work for human clinical trials. With Refunds for Research funding, Dr. Reginato will explore new, alternative treatment options for triple-negative breast cancer.

Thank you Drs. Fatatis and Reginato for working to find a cure for breast cancer now… so our daughters won’t have to!

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YOU can make a real difference this tax season. Donate your state income tax refund to breast cancer research by choosing “Option A” on Line 32. Help us continue our fight against breast cancer! For more information on the PBCC’s Refunds for Research program, visit pbcc.me.refunds.

Hope for the Future: Supporting Outstanding Breast Cancer Researchers

Posted By on January 15th, 2015 at 10:30 am | 459 comments.

patheadshotforplBy Pat Halpin-Murphy, President & Founder

Busy doesn’t even begin to describe a day in the life of a cancer researcher. Between studying cells, conducting lab trials and applying for grants, they work ’round the clock in their search for a cure.
And they need our help. Desperately. You can donate directly to Pennsylvania scientists through the PBCC’s Refunds for Research campaign. How? Find line 32 on your state income tax form and choose code “A.” The average donation is $7 and every penny makes a difference. Take action and donate your refund to breast cancer researchers in PA. Together, we can eliminate this disease and find a cure for breast cancer now… so our daughters won’t have to.

In 2015, the PBCC will fund $50,000 grants to each of these three researchers:
Alessandro Fatatis, M.D., Ph.D., Professor of Pharmacology & Physiology, Drexel University College of Medicine
Xianxin Hua, M.D., Ph.D., Professor of Cancer Biology, Perelman School of Medicine at the University of Pennsylvania
Mauricio Reginato, Ph.D., Associate Professor of Biochemistry and Molecular Biology, Drexel University College of Medicine

Join the PBCC Wednesday, January 28 at 10:00am at Drexel University as we award our first two research grants to Dr. Fatatis and Dr. Reginato! To RSVP, email Erica@PABreastCancer.org or call 800-377-8828 x2307.

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It’s Tax Day! PBCC Awards Third $50,000 Grant to Penn Medicine Breast Cancer Researcher

Posted By on April 15th, 2014 at 8:33 am | 10380 comments.

Pat Halpin-Murphy, President & FounderBy Pat Halpin-Murphy, President & Founder

Every time I walk into the laboratory of a breast cancer researcher, I am inspired. Their passion to find a cure for this disease is what drives them every day. On this Tax Day, we hope that you will join us in taking action on their behalf through the PA Breast Cancer Coalition’s Refunds for Breast Cancer Research program.

We hope you will join us and make the commitment to take action. Donate your state income tax refund on Line 32 to Refunds for Research and help us find a cure for breast cancer now… so our daughters won’t have to.

This past week, the PBCC visited the Abramson Cancer Family Research Institute at the University of Pennsylvania to award Dr. Lewis Chodosh with a $50,000 grant for his excellent work studying breast cancer recurrence. With continued support, his discoveries may someday be able to prevent breast cancer from coming back years later.

Learn more about Dr. Chodosh’s research on breast cancer recurrence in the video below.

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Take the Tax Challenge: Donate Your Refund to Breast Cancer Research

Posted By on March 14th, 2014 at 8:23 am | 259 comments.

Pat Headshot$8.00. That’s the average Refunds for Breast Cancer Research donation from Pennsylvania taxpayers on the state income tax form. It may not seem like a large amount, but the PA Breast Cancer Coalition has been able to turn those $8 donations into over $3 million in grants for outstanding PA breast cancer researchers working to find a cure.

We’re asking YOU to take the PBCC tax challenge this month. If you haven’t already done your taxes, look for Line 32 on the PA-40 form and consider making a difference for breast cancer survivors and their families. From there, share the message with friends and family.

How can you spread the word?

Share our :30 video PSA on Facebook and Twitter

– Tell your tax preparer about the importance of Line 32

– Take a proud picture with your tax form and email it to Info@PABreastCancer.org!
Every time you share the PBCC’s message, you’ll be entered to win a free registration to our 2014 Conference in Harrisburg!

Will YOU help us spread the word? Share our :30 video and make a difference beyond your donation. Thank you for supporting outstanding breast cancer researchers in Pennsylvania.

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Funding the Fight: How You Can Help Researchers Find a Cure for Breast Cancer

Posted By on February 17th, 2014 at 8:57 am | 294 comments.

By Pat Halpin-Murphy, President & Founder

Pat HeadshotFor breast cancer survivors and our families, hope plays a crucial role in navigating the diagnosis and what comes next. Many of us wouldn’t be where we are today without the discoveries of breast cancer researchers working to provide that hope in labs across Pennsylvania. We look to them for new treatments and, ultimately, a cure.

That is why the PA Breast Cancer Coalition created Refunds for Breast Cancer Research. It allows Pennsylvania residents to donate all or part of their state income tax refunds directly to scientists within our state. The average donation is $8, and together we have raised more than $3 million to fund basic research that leads to breakthroughs of the future.

Many of you have asked, “What if I don’t receive a state income tax refund?” There’s still a chance for you to support Pennsylvania’s breast cancer researchers.

CLICK HERE to contribute to Refunds for Research.

PA Breast Cancer Survivor Dr. Nikki Shaffer shares her message on the importance of Refunds for Research below. Click on the video for her story.

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