Triple-Negative Breast Cancer Clinical Trial Calling for Participants

Posted By on February 28th, 2014 at 9:25 am | 161 comments.
Clinical-Trial-Photo-1

Drs. Edith Mitchell, Hallgeir Rui and their team of multidisciplinary researchers

An ongoing research program, led by Edith Mitchell, M.D., FACP, Clinical Professor of Medicine and Clinical Oncology at the Kimmel Cancer Center at Jefferson and Hallgeir Rui, M.D., Ph.D., Professor of Cancer Biology, has initiated a new clinical trial at the Kimmel Cancer Center at Thomas Jefferson University that offers a more customized and personalized approach to the treatment of triple-negative breast cancer. The trial, with lead investigators Drs. Tiffany Avery in the Department of Medical Oncology and Adam Berger in the Department of Surgery, offers treatment in the form of chemotherapy paired with a supplemental medication called a “Parp Inhibitor” and is designed to target the breast cancer cells to increase response to treatment and decrease the risk of recurrence. Researchers will conduct a randomized two-arm trial in 12-week cycles by administering different types of medicines in addition to chemotherapy.

Triple-negative breast cancer cells lack estrogen receptors and progesterone receptors, and do not have an excess of the HER2 protein on their surfaces. This type of breast cancer diagnosis is more prevalent in younger women and in African-American women. Triple-negative breast cancers tend to grow faster and more aggressively and spread to other parts of the body more quicker than most other types of breast cancer. Drs. Mitchell and Rui and their team of researchers are hoping to increase the efficiency and effectiveness of treatment for triple-negative breast cancer through this clinical trial.

DSC04675

Dr. Edith Mitchell speaks with a patient at the Kimmel Cancer Center.

Clinical Trial Details:

An adaptive randomized Phase II Trial to determine pathologic complete response with the addition of carboplatin with and without veliparib to standard chemotherapy in the neoadjuvant treatment of triple-negative breast cancer
Study Design:  This is a randomized two-arm trial for the neoadjuvant treatment of triple breast cancer patients. The two arms for the trial are as follows:

1.    Paclitaxel and carboplatin (12 weekly cycles) with growth factor support followed by doxorubicin and cyclophosphamide (4 cycles every 3 weeks) with growth factor support.

2.    Veliparib + paclitaxel + carboplatin (12 weekly cycles) with growth factor support fol

lowed by doxorubicin and cyclophosphamide (4 cycles every 3 weeks) with growth factor support.

DSC04687

Drs. Edith Mitchell, Adam Berger & Hallgeir Rui

The primary objective of the study is to compare the pathologic complete response in patients with triple negative breast cancer treated with paclitaxel and carboplatin or paclitaxel, carboplatin, and veliparib in addition to standard

Dr. Avery

Dr. Tiffany Avery, a lead investigator in this clinical trial

chemotherapy  (adriamycin and cyclophosphamide).
Key Eligibility Criteria:
1. Histologically confirmed adenocarcinoma of the breast with the following markers: Estrogen receptor negative (<1%), progesterone receptor negative (<1%), and Her-2/neu negative (0, 1+ on IHC te

sting or 2+ and FISH ratio < 1.8) or adenocarcinoma identified as basal-like subtype on molecular profiling.
2.    Clinical stage IIA, IIB or stage IIIA, IIIB, or IIIC breast cancer with no prior treatment for this tumor.
3.   ECOG Performance Status of 0 or 1.

If you think you may be a potential candidate for this clinical study, please contact the study coordinator, Melisa Mordenti, at 215-955-8979.

Click on the video below for more details on this clinical trial.

Researchers-thumbnail-with-play-button

 

161 Responses

  1. tiffany jewelry on sale

    One of the passengers is from Denmark, spokesman Ram Hari Sharma said. The rest of those on board are from Nepal.

  2. michael kors spring 2014 catalog

    B d lululemon oops U p anchorage lululemon W 3 buy lululemon groovy run short GH 6 how much do lululemon shorts cost Z q bellevue square lululemon

  3. uggs for cheap

    Its such as you learn my thoughts! You appear to know so much about this, such as you wrote the ebook in it or something. I think that you could do with some percent to drive the message house a bit, however other than that, that is wonderful blog. A g…

  4. eFRqFcGO says:

    eFRqFcGO

    Triple-Negative Breast Cancer Clinical Trial Calling for Participants – PA Breast Cancer Coalition Blog

  5. discount uggs

    uggs sale

  6. ugg boots for men

    I have been reading out some of your stories and i can state clever stuff. I will surely bookmark your website.

  7. michael kors purses

    You have observed very interesting details! ps decent internet site.

  8. cheap wow gold

    cheap wow gold ARE TRUELY Stunning AND Well Value Extremely COMFTY,Very easy to SLIP ON And even Choose Just about anyplace.And also the Trainers Are a lot easier Considerably better After that Any specific cheap wow gold IVE HAD They’ve been Rather C…

  9. buy wow gold says:

    buy wow gold

    True love some of these buy wow gold and grab lots of flatters.

  10. cheap louis vuitton

    Beowulf is the story of a great king who fought against monsters. He was a good king, well liked by his people. A new book by Seamus Heaney tells this ancient story in modern English.

  11. cheap fifa 15 coins

    So as on your behalf to become an exceptional golfer, you should know the requirements that will help you to accomplish your tennis goals.

  12. michael kors uk

    Regards for helping out, wonderful information.

  13. michael kors handbags

    You have mentioned very interesting points ! ps decent website . “‘Tis a sharp medicine, but it will cure all that ails you. — last words before his beheadding” by Sir Walter Raleigh.

  14. michael kors says:

    michael kors

    I really like your writing style, wonderful info , thanks for posting : D.

  15. michael kors bag

    I genuinely enjoy reading through on this internet site , it holds good content . “Heavier-than-air flying machines are impossible.” by Lord Kelvin.

  16. michael kors factory outlet

    I like this weblog very much, Its a real nice office to read and find information. “Nunc scio quit sit amor.” by Virgil.

  17. porn video says:

    porn video

    adult video porn video porn video porn video porn video porn video porn video porn video adult video adult video porn video porn video adult video porn video porn video adult video

  18. ugg boots uk says:

    ugg boots uk

    Some truly interesting information, well written and broadly user friendly.

  19. canada goose coat

    Very interesting topic , regards for posting . “Everything in the world may be endured except continued prosperity.” by Johann von Goethe.

  20. uggs for women

    Loving the information on this web site, you have done outstanding job on the blog posts.

  21. uggs outlet says:

    uggs outlet

    ugg outlet online

  22. alpine project north face

    R p Y h lululemon employee discount percentage Y 7 Y n lululemon england P 9

  23. michael kors bags

    I’ve recently started a site, the info you provide on this website has helped me tremendously. Thanks for all of your time & work.

  24. michael kors outlet

    You are my inspiration, I own few blogs and sometimes run out from brand :). “‘Tis the most tender part of love, each other to forgive.” by John Sheffield.

  25. michael kors purse

    I’ve recently started a blog, the info you offer on this web site has helped me tremendously. Thank you for all of your time & work. “There can be no real freedom without the freedom to fail.” by Erich Fromm.

  26. michael kors handbags outlet

    Very wonderful information can be found on web site. “You have to learn that if you start making sure you feel good, everything will be okay.” by Ruben Studdard.

  27. Legend Blue 11s

    https://code.google.com/p/legendblue11sonline/ zffjkqm Pre Order Legend Blue 11s wpywibyj

  28. ugg outlet says:

    ugg outlet

    Only a smiling visitant here to share the love (:, btw great design .

  29. ugg sale says:

    ugg sale

    What’s Taking place i’m new to this, I stumbled upon this I’ve discovered It absolutely useful and it has helped me out loads. I’m hoping to give a contribution & help different users like its helped me. Good job.

  30. retro 11 snakeskin green

    C b irregular north face A r north face ripstop cargo pants P n nyc north face store J q B 1

  31. moncler pas cher

    The specter of the deadly April 1992 riots in Los Angeles, which broke out after a similarly racially-charged case, still lingers among law enforcement officials.

  32. uggs australia

    I wanted to follow up and allow you to know how , a great deal I appreciated discovering your site today. I would consider it a real honor to work at my office and be able to utilize tips contributed on your web site and also get involved in visitors’…

  33. uggs sale says:

    uggs sale

    naturally like your web site however you need to check the spelling on several of your posts. Several of them are rife with spelling problems and I in finding it very troublesome to tell the truth nevertheless I’ll certainly come again again.

  34. cheap wow gold

    I had cheap wow gold by 50 % styles

  35. adult video says:

    adult video

    adult video porn video adult video adult video porn video adult video adult video porn video porn video porn video porn video porn video adult video adult video porn video porn video

  36. dior handbags sale usa

    Great seller.

  37. calgary denture clinic

    […]calgary denture clinic[…]

  38. hermes accessories hermes bags accessories

    birkin 35cm clemence leather hermes light coffee gold birkin 35cm clemence leather hermes gray gold birkin 35cm clemence hermes leather dark blue gold birkin 35cm clemence leather dark blue silver hermes birkin 35cm clemence hermes leather hot pink sil…

  39. How To Get Legend Blue 11s

    http://legendblue11.makesit.net/ lrxgxw Jordan 11 Legend Blue wfahdxtcemm

  40. adult video says:

    adult video

    porn video adult video adult video porn video porn video porn video porn video porn video adult video adult video porn video adult video adult video porn video adult video adult video

  41. mens uggs says:

    mens uggs

    Great website! I am loving it!! Will be back later to read some more. I am bookmarking your feeds also

  42. uggs for men says:

    uggs for men

    You have brought up a very fantastic details, thank you for the post.

  43. christian pompe june python 100mm louboutin or

    christian escarpin ron louboutin ron veau velours 100mm jaune christian escarpin louboutin samira strass 100mm christian escarpin louboutin ron ron veau velours 100mm jaune 434 christian escarpin samira louboutin strass 100mm christian escarpin loubout…

  44. cheap uggs says:

    cheap uggs

    ugg outlet locations

  45. ugg boots sale

    I think other website owners should take this site as an example, very clean and great user pleasant design.

  46. cheap uggs says:

    cheap uggs

    jordans 11

  47. abercrombie las vegas cyber monday 2014

    By Alexander Pyles and The Baltimore Sun August 24, 2014

  48. michael kors wallet

    I think you have observed some very interesting points , appreciate it for the post.

  49. michael kors outlet online

    Perfectly indited articles , thanks for entropy.

  50. cheap uggs says:

    cheap uggs

    I was looking through some of your posts on this site and I believe this website is rattling instructive! Keep on putting up.

  51. ugg outlet says:

    ugg outlet

    I am no longer sure where you’re getting your information, however great topic. I needs to spend a while learning more or understanding more. Thanks for fantastic information I used to be looking for this info for my mission.

  52. Legend Blue 11s 2014

    http://www.steevliet.be/adidasworldcupsoccershoes.htm xtnnqcqbhw Real Legend Blue 11s gytpsosfse

  53. timberland roll top femme

    This is useful. Some realize there were A whole lot of wrong or maybe negative using the ipad tablet. I mean, That i knew ?t had been a kind of things you terribly lack some sort of make use of intended for, you need to find a work with for this. . -=…

  54. the north face apex bionic promotional code jackets magenta

    A 9 erin mills town centre lululemon I 7 C s deep breath tank lululemon W 2 lululemon camo Z r lululemon oops

  55. ugg boots for women

    I gotta bookmark this site it seems very useful invaluable.

  56. moncler ipo eurazeo

    Thanks for your personal marvelous posting! I seriously enjoyed reading it, you’re a great author.I will ensure that I bookmark your blog and will eventually come back someday. I want to encourage you to definitely continue your great posts, have a ni…

  57. ugg australia

    ugg outlet

  58. air jordan 11

    ugg boots

  59. ugg outlet says:

    ugg outlet

    canada goose coat

  60. cheap wildstar gold

    Nicole Dennie, Hugely vibrantly introduced via G. w. Putnam s daughters, I have used Second everyday living in almost four weeks and weeks, And tend to be walking the device on Windows windows vis for a while(Beginning with RC1). Nvidia has got emitted…

  61. diablo 3 news

    Gaming is a no brainer: Instead of high traffic the first couple of weeks appropriate promptly straight because of discharge, Available wasn’t a good deal of hold it to receive over to the hosts i am only jamming. Seriously through the first week, The…

  62. Zentai Suit Sale

    Investigating an old school astronaut suit recently, It occurred to me you can actually make a pretty decent mockup with duct tape. Very honestly, Something such as this isn’t really so different from a product like this. People made an old school whi…

  63. ugg boots uk says:

    ugg boots uk

    I have recently started a blog, the information you offer on this web site has helped me tremendously. Thank you for all of your time & work.

  64. uggs on sale says:

    uggs on sale

    cheap uggs

  65. cheap ugg boots uk

    I adore reading through and I believe this website got some genuinely utilitarian stuff on it!

  66. jordan concords

    Dead composed content, appreciate it for information. “In the fight between you and the world, back the world.” by Frank Zappa.

  67. timberland pas cher

    Had difficulties to be able to earlier mentioned, disabled Kservice, then found spoolsv. exe wanting to phone away. Checked out upward and found its some sort of respectable Ms software with regard to printer/fax spooling. Nonetheless it was dialling 1…

  68. michael kors sale uk

    Once only an analog , the heart of most telephone s today is all digital. Lovely, it a little bling-y for my taste but really, you can fault the quality.

  69. icrcilot.pen.io

    en transit et une cinquantaine de morts.

  70. cheap nfl jerseys online

    Japan is situated at the meeting place of several of the Earth’s tectonic plates and experiences a number of relatively violent quakes every year.

  71. Air Max Australia

    There are many of brand names of cheap Trainer Purses, Bags and Handbags, so that you can purchase most favorite manufacturer. You can pay for to buy coach hand bags that accentuate all of your casual and formal dresses as they come with really low rat…

  72. uggs uk says:

    uggs uk

    Great – I should definitely pronounce, impressed with your web site. I had no trouble navigating through all tabs and related information ended up being truly simple to do to access. I recently found what I hoped for before you know it at all. Quite un…

  73. nike air jordan collezione 21

    Nicht nur, dass die Erdkruste sitzen auf einem Bett von Fl眉ssigkeit Rock in st盲ndiger Bewegung, aber seine Oberfl盲che ist auch wie Puzzleteile genannt tektonischen Platten gebrochen. Und diese Puzzleteile passen nicht perfekt oder sicher zusammen.

  74. cheap fifa 15 coins

    Walking, sprinting or just wearing them all through the working day as you conduct your every day chores can grant your muscle cells a little further more exercise.

  75. cheap fifa 15

    The disadvantages and advantages of bloom formation

  76. ugg says:

    ugg

    I am so happy to read this. This is the type of manual that needs to be given and not the random misinformation that is at the other blogs. Appreciate your sharing this best doc.

  77. is michael kors a zionist

    D q goose leather jackets juniors S d canada goose outlet parka Z 1 Y 1 M e

  78. ugg australia

    ugg boots for women

  79. uggs on sale says:

    uggs on sale

    Thank you for the sensible critique. Me and my neighbor were just preparing to do a little research on this. We got a grab a book from our area library but I think I learned more from this post. I am very glad to see such fantastic info being shared fr…

  80. ugg hannen zalando

    Does your blog have a contact page? I’m having problems locating it but, I’d like to shoot you an email. I’ve got some suggestions for your blog you might be interested in hearing. Either way, great site and I look forward to seeing it develop over…

  81. uggs outlet says:

    uggs outlet

    Some really choice articles on this site, bookmarked.

  82. adult video says:

    adult video

    porn video adult video adult video porn video adult video adult video porn video porn video adult video porn video porn video porn video adult video adult video porn video adult video

  83. wholesale nfl jerseys

    The Boeing 777 vanished March 8 while flying from Kuala Lumpur, Malaysia, to Beijing with 239 people on board. The focus of the search changed repeatedly. It began in the South China Sea, then shifted toward the Strait of Malacca to the west, and then…

  84. hollister perfume cyber monday 2014

    Elle poursuit sa lutte “contre l tation” de l dans ses deux livres consacr s la maladie Illness as Metaphor (1978) et AIDS and Its Metaphors (1988), en cherchant tendre son analyse au “monde r el”, celui du corps. Pour elle, il ne faut consid rer l…

  85. comprar ugg australia

    My spouse and I stumbled over here different web address and thought I might check things out. I like what I see so now i’m following you. Look forward to finding out about your web page for a second time.

  86. cheap air jordan 11 space jams sale

    GH z A o jordan 11 concord restock date K j X m A p

  87. cheap moncler jackets

    Triple-Negative Breast Cancer Clinical Trial Calling for Participants – PA Breast Cancer Coalition Blog

  88. cheap timberland boots

    Managing terms and conditions lets you know from the p2p, the belief that most likely eliminated coming from maintaining that (short involving editing new venture with msconfig) is a crucial concern.

  89. doudoune parajumpers gobi

    We work with ESX5 having Windows Hard drive Machine ISCSI objectives without having troubles. I assume “mileage may possibly vary” does apply in this article.

  90. cartier jewelry replica uk

    Thank you! Highly recommend! Super fast shipping.

  91. gucci boston bag material

    Im Alter von 66 nach einer Schlacht mit Darmkrebs, Geoff Hollister, einer der Original Nike F眉hrungskr盲fte. Nach der Hauptrolle in den 60er Jahren als L盲ufer f眉r Bill Bowerman, Oregon Track Trainer arbeitete Hollister in Kommission verkaufen Laufschuhe…

  92. ugg augustine canada

    I will right away grasp your rss as I can’t find your e-mail subscription link or newsletter service. Do you have any? Please permit me recognize so that I may just subscribe. Thanks.

  93. ugg boots for women

    thank you for this post, I am a big fan of this internet site would like to go along updated.

  94. adult video says:

    adult video

    porn video adult video adult video adult video adult video porn video porn video adult video porn video adult video adult video porn video adult video adult video adult video porn video

  95. abercrombie ireland cyber monday deals

    P. se origin la Oraci de la Serenidad?

  96. black infrared 6s

    A stone cold, merciless killer is a chilling thought, but when they start spouting super villain style dialogue and cringe worthy rejoinders, it just takes the threat right out of them. “Nothing is scripted. The faster you get to heal your burns the b…

  97. ugg boots on sale

    I think this internet site has got very good indited content content.

  98. Cyber Monday jordan shoes store

    Kee peered out into the morning darkness, broken only by a thin, crooked line of light outlining the ridge of the mesa in the distance.

  99. fifa coins online

    Here at Battilay, we have been selling Fifa Coins due to the fact 2010 : we are one of several oldest position Fifa money merchants. In this years of selling FUT coins now we have learnt many items on the way, in addition to we’re confident that you’…

  100. ugg snow boots

    ugg outlet

  101. Pre Order Legend Blue 11s

    http://legendblue11s.portfolik.com/ bcdnfaniq Legend Blue 11 kkxqhelw

  102. uggs for cheap

    Of course, what a splendid website and revealing posts, I surely will bookmark your blog.Have an awsome day!

  103. ugg australia

    Wow! Thank you! I constantly wanted to write on my site something like that. Can I take a portion of your post to my blog?

  104. mulberry uk says:

    mulberry uk

    There exists a internet site in development to mulberry ukday referred to mulberry uk as BEATPLAY that’s going to mulberry uk be considered a useful gizmo with regard to mulberry uk independent musicians to mulberry uk show off all their audio without…

  105. ugg classic cardy sequins

    An interesting discussion is definitely worth comment. I do think that you ought to publish more about this topic, it may not be a taboo subject but generally people do not talk about such topics. To the next! Best wishes!!

  106. timberland boots outlet

    In addition, with regards to timberland boots outlet performing traditional bac ups, it truly is definitely an understanding. But that wont guide Sparring floor Honan in the event the option in addition to timberland boots outlet scarier circumstance h…

  107. hollister staffing cyber monday deals

    ATTENTION ! Ce qui suit est un Very Big Post pour un Very Big Project qui s’est bien fait attendre, 4 jours de couture, non mais vous vous rendez compte ? 4 jours !

  108. Woolrich Arctic Parka

    The threat of inflation was a worry for Chinese authorities in the first half of 2008. But price growth faltered in the second half as global financial markets were routed and international commodity prices eased. The central bank has cut interest rate…

  109. fifa coins store

    3 or more guards definitely could not work with the issues

  110. uggs canada says:

    uggs canada

    You can certainly see your enthusiasm in the work you write. The sector hopes for more passionate writers such as you who aren’t afraid to say how they believe. All the time follow your heart.

  111. ugg bailey button

    Wow! This could be one particular of the most helpful blogs We have ever arrive across on this subject. Actually Wonderful. I am also an expert in this topic so I can understand your hard work.

  112. ugg boots says:

    ugg boots

    Definitely, what a magnificent website and instructive posts, I definitely will bookmark your blog.All the Best!

  113. michael jordan shoes europe

    Termini Bros. Bakery is the proud winner of 15 Best of Philly awards by Philadelphia Magazine, and was recently selected for its Hall of Fame. The bakery uses equipment dating back to the early 1900s, and uses recipes dating back to the 1800s. It is we…

  114. ugg store says:

    ugg store

    ugg outlet

  115. ugg classic short

    Very superb visual appeal on this website, I’d value it 10.

  116. moncler usa store locator

    Great post. I was checking continuously this blog and I’m impressed! Extremely useful information particularly the last part :) I care for such info a lot. I was seeking this particular information for a long time. Thank you and best of luck.

  117. prada handbags outlet

    thank you so much, excellent seller fast shipping AAAAA+++++

  118. Pagerank

    […]pagerank webstats webvalue rank webmaster tool web value , website valuation , website […]

  119. moncler jakke sælges

    My programmer is trying to persuade me to move to .net from PHP. I have always disliked the idea because of the costs. But he’s tryiong none the less. I’ve been using WordPress on a variety of websites for about a year and am anxious about switching…

  120. uggs for women

    I am only writing to make you be aware of what a outstanding encounter my friend’s princess enjoyed reading through your blog. She learned some issues, which include how it is like to possess an ideal teaching nature to get men and women effortlessly…

  121. cheap air max shoes

    The mood was far from the euphoria of March 1999, when the Dow surpassed 10,000 for the first time. The Internet then was driving extraordinary gains in productivity, and serious people debated whether there was such a thing as a boom without end.

  122. gucci ballerina shoes uk

    In particolare Rayban si aspetta una crescita delle vendite a una cifra, grazie alle nuove collezioni e ai mercati emergenti. Oakley punta a registrare una crescita a doppia cifra, complici gli investimenti in design e innovazione mentre per Armani sti…

  123. woolrich arctic parka sand

    Outstanding post but I was wanting to know if you could write a litte more on this topic? I’d be very thankful if you could elaborate a little bit more. Cheers!

  124. cheap timberland boots

    Hi, immediately after improving for you to cheap timberland boots iOS several. three or more. a single, I ran across the particular camera jiggle is actually vacant, it will probably be launching… ‘ once and for all even though seeking to cheap timb…

  125. ugg boots outlet

    I believe this is one of the so much important information for me. And i am satisfied reading your article. But should observation on some basic things, The site style is wonderful, the articles is in reality great :D. Excellent job, cheers.

  126. moncler jakke aarhus

    Your means of explaining everything in this paragraph is actually fastidious, every one can simply understand it, Thanks a lot.

  127. woolrich outlet

    Alex Hall and Winston Milling, both friends with Harris since college and who worked with him at a Home Depot store, testified that Harris talked all the time about how he loved his son. The two went to lunch with Harris the day the boy died and had pl…

  128. uggs canada says:

    uggs canada

    I am so happy to read this. This is the kind of manual that needs to be given and not the random misinformation that is at the other blogs. Appreciate your sharing this best doc.

  129. piumini moncler Outlet

    China’s health authorities have promised transparency and cooperation to the World Health Organization.

  130. ugg sale says:

    ugg sale

    Thank you for another wonderful article. The place else may anybody get that kind of info in such a perfect means of writing? I’ve a presentation subsequent week, and I’m on the search for such information.

  131. timberland roll top femme

    Grooveshark does suggest audio for you based upon things that are previously in your playlist should you click on the radio press button and won’t influence any variety.

  132. uggs on sale says:

    uggs on sale

    Thanks, I’ve just been looking for information about this subject for a while and yours is the best I’ve discovered till now. But, what concerning the bottom line? Are you positive in regards to the source?