Triple-Negative Breast Cancer Clinical Trial Calling for Participants

Posted By on February 28th, 2014 at 9:25 am | 69 comments.
Clinical-Trial-Photo-1

Drs. Edith Mitchell, Hallgeir Rui and their team of multidisciplinary researchers

An ongoing research program, led by Edith Mitchell, M.D., FACP, Clinical Professor of Medicine and Clinical Oncology at the Kimmel Cancer Center at Jefferson and Hallgeir Rui, M.D., Ph.D., Professor of Cancer Biology, has initiated a new clinical trial at the Kimmel Cancer Center at Thomas Jefferson University that offers a more customized and personalized approach to the treatment of triple-negative breast cancer. The trial, with lead investigators Drs. Tiffany Avery in the Department of Medical Oncology and Adam Berger in the Department of Surgery, offers treatment in the form of chemotherapy paired with a supplemental medication called a “Parp Inhibitor” and is designed to target the breast cancer cells to increase response to treatment and decrease the risk of recurrence. Researchers will conduct a randomized two-arm trial in 12-week cycles by administering different types of medicines in addition to chemotherapy.

Triple-negative breast cancer cells lack estrogen receptors and progesterone receptors, and do not have an excess of the HER2 protein on their surfaces. This type of breast cancer diagnosis is more prevalent in younger women and in African-American women. Triple-negative breast cancers tend to grow faster and more aggressively and spread to other parts of the body more quicker than most other types of breast cancer. Drs. Mitchell and Rui and their team of researchers are hoping to increase the efficiency and effectiveness of treatment for triple-negative breast cancer through this clinical trial.

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Dr. Edith Mitchell speaks with a patient at the Kimmel Cancer Center.

Clinical Trial Details:

An adaptive randomized Phase II Trial to determine pathologic complete response with the addition of carboplatin with and without veliparib to standard chemotherapy in the neoadjuvant treatment of triple-negative breast cancer
Study Design:  This is a randomized two-arm trial for the neoadjuvant treatment of triple breast cancer patients. The two arms for the trial are as follows:

1.    Paclitaxel and carboplatin (12 weekly cycles) with growth factor support followed by doxorubicin and cyclophosphamide (4 cycles every 3 weeks) with growth factor support.

2.    Veliparib + paclitaxel + carboplatin (12 weekly cycles) with growth factor support fol

lowed by doxorubicin and cyclophosphamide (4 cycles every 3 weeks) with growth factor support.

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Drs. Edith Mitchell, Adam Berger & Hallgeir Rui

The primary objective of the study is to compare the pathologic complete response in patients with triple negative breast cancer treated with paclitaxel and carboplatin or paclitaxel, carboplatin, and veliparib in addition to standard

Dr. Avery

Dr. Tiffany Avery, a lead investigator in this clinical trial

chemotherapy  (adriamycin and cyclophosphamide).
Key Eligibility Criteria:
1. Histologically confirmed adenocarcinoma of the breast with the following markers: Estrogen receptor negative (<1%), progesterone receptor negative (<1%), and Her-2/neu negative (0, 1+ on IHC te

sting or 2+ and FISH ratio < 1.8) or adenocarcinoma identified as basal-like subtype on molecular profiling.
2.    Clinical stage IIA, IIB or stage IIIA, IIIB, or IIIC breast cancer with no prior treatment for this tumor.
3.   ECOG Performance Status of 0 or 1.

If you think you may be a potential candidate for this clinical study, please contact the study coordinator, Melisa Mordenti, at 215-955-8979.

Click on the video below for more details on this clinical trial.

Researchers-thumbnail-with-play-button

 

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    {Is this|Is that this} a paid {subject|topic|subject matter|theme} or did you {customize|modify} it {yourself|your self}?
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    a {nice|great} {blog|weblog} like this one {these days|nowadays|today}..|
    {Hi|Hello}, Neat post. {There is|There’s} {a problem|an issue} {with
    your|together with your|along with your} {site|web site|website} in {internet|web} explorer,
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  61. あなたのためにあなたはライターを探しているなら、私に知らせてください。 記事と私は|あなたはいくつかの本当に良い素晴らしいを持つ感じ私は良い資産になる。戻って鉱山へのリンクと引き換えにあなたのブログのための いくつかの書き込みにあなたがこれまで負荷の一部を取るしたい場合は、私が愛と思います。 爆発してください私にメール興味あれば。 ありがとうござい!
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  62. ちょうどあなたの記事より少し多くを| 追加などについて|あなたは今まで思想とみなさがありますか?とすべて、私はあなたが が言うことを意味する。またはグラフィックあなたはいくつかの素晴らしいを追加した場合それにもかかわらず、|より多くのあなたの記事を与えるために、ビデオクリップ動画 “ポップ、について考える “!あなたのコンテンツが優れているがと写真と動画、このでしたウェブサイトのブログのいずれかである最高フィールド|そのニッチ最高。 極上ブログ!
    バレンシアガ 男性

  63. こんにちは!私はこれにしてきた宣誓かもしれない前に、しかし後にブログサイトウェブサイト{読書|ブラウジング|チェックポストのいくつかを、私はそれが私には新機能が実現。 とにかく、私は間違いだ喜ん私はそれを発見し、私はなるだろうブックマークとバックチェックしばしば!
    クロムハーツ 長袖

  64. コマーシャルトリガー私ブラウザその上置きたい、サイズを変更あなたのいずれかを|私は信じていると思いあなたのブラックリスト。
    メガネ レイバン 激安

  65. リーダー、優れたのもの、私の にサイト私はちょうどこれを追加しました。 できない十分に得る!
    アンテプリマ 財布 中古

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